Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

BACKGROUND: Pancreatic ductal adenocarcinomas (PDA) activate a glutamine-dependent pathway of cytosolic nicotinamide adenine dinucleotide phosphate (NADPH) production to maintain redox homeostasis and support proliferation. Enzymes involved in this pathway (GLS1 (mitochondrial glutaminase 1), GOT1 (...

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Publicat a:Cancer Metab
Autors principals: Chakrabarti, Gaurab, Moore, Zachary R., Luo, Xiuquan, Ilcheva, Mariya, Ali, Aktar, Padanad, Mahesh, Zhou, Yunyun, Xie, Yang, Burma, Sandeep, Scaglioni, Pier P., Cantley, Lewis C., DeBerardinis, Ralph J., Kimmelman, Alec C., Lyssiotis, Costas A., Boothman, David A.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601138/
https://ncbi.nlm.nih.gov/pubmed/26462257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-015-0137-1
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