Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

BACKGROUND: Pancreatic ductal adenocarcinomas (PDA) activate a glutamine-dependent pathway of cytosolic nicotinamide adenine dinucleotide phosphate (NADPH) production to maintain redox homeostasis and support proliferation. Enzymes involved in this pathway (GLS1 (mitochondrial glutaminase 1), GOT1 (...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Chakrabarti, Gaurab, Moore, Zachary R., Luo, Xiuquan, Ilcheva, Mariya, Ali, Aktar, Padanad, Mahesh, Zhou, Yunyun, Xie, Yang, Burma, Sandeep, Scaglioni, Pier P., Cantley, Lewis C., DeBerardinis, Ralph J., Kimmelman, Alec C., Lyssiotis, Costas A., Boothman, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601138/
https://ncbi.nlm.nih.gov/pubmed/26462257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-015-0137-1
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