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Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells

Mitochondria play important roles in tumor cell physiology and survival by providing energy and metabolites for proliferation and metastasis. As part of their oncogenic status, cancer cells frequently produce increased levels of mitochondrial-generated reactive oxygen species (ROS). However, extensi...

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Détails bibliographiques
Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Ma, Jing, Lim, Chaemin, Sacher, Joshua R., Van Houten, Bennett, Qian, Wei, Wipf, Peter
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607627/
https://ncbi.nlm.nih.gov/pubmed/26159482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.06.073
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