Many Private Mutations Originate From The First Few Divisions Of A Human Colorectal Adenoma

Intratumoral mutational heterogeneity (ITH) or the presence of different private mutations in different parts of the same tumor is commonly observed in human tumors. The mechanisms generating such ITH are uncertain. Here we find ITH can be remarkably well-structured by measuring point mutations, chr...

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Vydáno v:J Pathol
Hlavní autoři: Kang, Haeyoun, Salomon, Matthew P., Sottoriva, Andrea, Zhao, Junsong, Toy, Morgan, Press, Michael F., Curtis, Christina, Marjoram, Paul, Siegmund, Kimberly, Shibata, Darryl
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607608/
https://ncbi.nlm.nih.gov/pubmed/26119426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4581
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