A Nano-MgO and Ionic Liquid-Catalyzed ‘Green’ Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51)

In this work, we describe the ‘green’ synthesis of novel 6-(adamantan-1-yl)-2-substituted-imidazo[2,1-b][1,3,4]thiadiazoles (AITs) by ring formation reactions using 1-(adamantan-1-yl)-2-bromoethanone and 5-alkyl/aryl-2-amino1,3,4-thiadiazoles on a nano material base in ionic liquid media. Given the...

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Udgivet i:PLoS One
Main Authors: Anusha, Sebastian, CP, Baburajeev, Mohan, Chakrabhavi Dhananjaya, Mathai, Jessin, Rangappa, Shobith, Mohan, Surender, Chandra, Paricharak, Shardul, Mervin, Lewis, Fuchs, Julian E., M, Mahedra, Bender, Andreas, Basappa, Rangappa, Kanchugarakoppal S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607480/
https://ncbi.nlm.nih.gov/pubmed/26470029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139798
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