Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway

Overactivation of PI3K/Akt/mTOR is linked with carcinogenesis and serves a potential molecular therapeutic target in treatment of various cancers. Herein, we report the synthesis of trisubstituted-imidazoles and identified 2-chloro-3-(4, 5-diphenyl-1H-imidazol-2-yl) pyridine (CIP) as lead cytotoxic...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mohan, Chakrabhavi Dhananjaya, Srinivasa, V., Rangappa, Shobith, Mervin, Lewis, Mohan, Surender, Paricharak, Shardul, Baday, Sefer, Li, Feng, Shanmugam, Muthu K., Chinnathambi, Arunachalam, Zayed, M. E., Alharbi, Sulaiman Ali, Bender, Andreas, Sethi, Gautam, Basappa, Rangappa, Kanchugarakoppal S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838272/
https://ncbi.nlm.nih.gov/pubmed/27097161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153155
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