Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5

p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the CDK5 or p35 (CDK5R1) genes induces abnormal neuronal layering in various regions of the mouse brain via impaired neuronal migration, which may...

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Veröffentlicht in:PLoS One
Hauptverfasser: Takada, Shunsuke, Mizuno, Keiko, Saito, Taro, Asada, Akiko, Giese, Karl Peter, Hisanaga, Shin-ichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607440/
https://ncbi.nlm.nih.gov/pubmed/26469698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140821
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