Commitment of 1-Methyl-4-phenylpyrinidinium Ion-induced Neuronal Cell Death by Proteasome-mediated Degradation of p35 Cyclin-dependent Kinase 5 Activator

The dysfunction of proteasomes and mitochondria has been implicated in the pathogenesis of Parkinson disease. However, the mechanism by which this dysfunction causes neuronal cell death is unknown. We studied the role of cyclin-dependent kinase 5 (Cdk5)-p35 in the neuronal cell death induced by 1-me...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Endo, Ryo, Saito, Taro, Asada, Akiko, Kawahara, Hiroyuki, Ohshima, Toshio, Hisanaga, Shin-ichi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2009
Gaiak:
Protein Synthesis, Post-Translational Modification, and Degradation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758003/
https://ncbi.nlm.nih.gov/pubmed/19638632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.026443
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