Effect of Pin1 or Microtubule Binding on Dephosphorylation of FTDP-17 Mutant Tau

Neurodegenerative tauopathies, including Alzheimer disease, are characterized by abnormal hyperphosphorylation of the microtubule-associated protein Tau. One group of tauopathies, known as frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), is directly associated with mutati...

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Detalhes bibliográficos
Main Authors: Yotsumoto, Kensuke, Saito, Taro, Asada, Akiko, Oikawa, Takayuki, Kimura, Taeko, Uchida, Chiyoko, Ishiguro, Koichi, Uchida, Takafumi, Hasegawa, Masato, Hisanaga, Shin-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719320/
https://ncbi.nlm.nih.gov/pubmed/19401603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.003277
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