Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development

Tau is a microtubule (MT)-associated protein that regulates MT dynamics in the axons of neurons. Tau binds to MTs via its C-terminal MT-binding repeats. There are two types of tau, those with three (3R) or four (4R) MT-binding repeats; 4R tau has a stronger MT-stabilizing activity than 3R tau. The M...

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Udgivet i:J Biol Chem
Main Authors: Tuerde, Dilina, Kimura, Taeko, Miyasaka, Tomohiro, Furusawa, Kotaro, Shimozawa, Aki, Hasegawa, Masato, Ando, Kanae, Hisanaga, Shin-ichi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798307/
https://ncbi.nlm.nih.gov/pubmed/29196605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.798918
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