Isomerase Pin1 Stimulates Dephosphorylation of Tau Protein at Cyclin-dependent Kinase (Cdk5)-dependent Alzheimer Phosphorylation Sites

Neurodegenerative diseases associated with the pathological aggregation of microtubule-associated protein Tau are classified as tauopathies. Alzheimer disease, the most common tauopathy, is characterized by neurofibrillary tangles that are mainly composed of abnormally phosphorylated Tau. Similar hy...

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Main Authors: Kimura, Taeko, Tsutsumi, Koji, Taoka, Masato, Saito, Taro, Masuda-Suzukake, Masami, Ishiguro, Koichi, Plattner, Florian, Uchida, Takafumi, Isobe, Toshiaki, Hasegawa, Masato, Hisanaga, Shin-ichi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597833/
https://ncbi.nlm.nih.gov/pubmed/23362255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.433326
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