Suppression of Mutant Huntingtin Aggregate Formation by Cdk5/p35 through the Effect on Microtubule Stability

Huntington's disease (HD) is a polyglutamine [poly(Q)] disease with an expanded poly(Q) stretch in the N terminus of the huntingtin protein (htt). A major pathological feature of HD neurons is inclusion bodies, detergent-insoluble aggregates composed of poly(Q)-expanded mutant htt (mhtt). Misfo...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Kaminosono, Sayuko, Saito, Taro, Oyama, Fumitaka, Ohshima, Toshio, Asada, Akiko, Nagai, Yoshitaka, Nukina, Nobuyuki, Hisanaga, Shin-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670830/
https://ncbi.nlm.nih.gov/pubmed/18753376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0973-08.2008
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