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Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5

p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the CDK5 or p35 (CDK5R1) genes induces abnormal neuronal layering in various regions of the mouse brain via impaired neuronal migration, which may...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Takada, Shunsuke, Mizuno, Keiko, Saito, Taro, Asada, Akiko, Giese, Karl Peter, Hisanaga, Shin-ichi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607440/
https://ncbi.nlm.nih.gov/pubmed/26469698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140821
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