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Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5
p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the CDK5 or p35 (CDK5R1) genes induces abnormal neuronal layering in various regions of the mouse brain via impaired neuronal migration, which may...
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| Publicado en: | PLoS One |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4607440/ https://ncbi.nlm.nih.gov/pubmed/26469698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140821 |
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