Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5

p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the CDK5 or p35 (CDK5R1) genes induces abnormal neuronal layering in various regions of the mouse brain via impaired neuronal migration, which may...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Takada, Shunsuke, Mizuno, Keiko, Saito, Taro, Asada, Akiko, Giese, Karl Peter, Hisanaga, Shin-ichi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607440/
https://ncbi.nlm.nih.gov/pubmed/26469698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140821
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items