Phase Transitions of Spindle-Associated Protein Regulate Spindle Apparatus Assembly

Spindle assembly required during mitosis depends on microtubule polymerization. We demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes phase transition or coacervation to promote assembly of both spindles and their associated components. BuGZ forms temperature-depen...

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Vydáno v:Cell
Hlavní autoři: Jiang, Hao, Wang, Shusheng, Huang, Yuejia, He, Xiaonan, Cui, Honggang, Zhu, Xueliang, Zheng, Yixian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607269/
https://ncbi.nlm.nih.gov/pubmed/26388440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.08.010
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