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RanGTP aids anaphase entry through Ubr5-mediated protein turnover
RanGTP is known to regulate the spindle assembly checkpoint (SAC), but the underlying molecular mechanism is unclear. BuGZ stabilizes SAC protein Bub3 through direct interaction and facilitates its mitotic function. Here we show that RanGTP promotes the turnover of BuGZ and Bub3 in metaphase, which...
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| Опубликовано в: : | J Cell Biol |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4602037/ https://ncbi.nlm.nih.gov/pubmed/26438829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201503122 |
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