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Splicing function of mitotic regulators links R-loop–mediated DNA damage to tumor cell killing
Although studies suggest that perturbing mitotic progression leads to DNA damage and p53 activation, which in turn lead to either cell apoptosis or senescence, it remains unclear how mitotic defects trigger p53 activation. We show that BuGZ and Bub3, which are two mitotic regulators localized in the...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4411280/ https://ncbi.nlm.nih.gov/pubmed/25918225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201409073 |
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