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Splicing function of mitotic regulators links R-loop–mediated DNA damage to tumor cell killing
Although studies suggest that perturbing mitotic progression leads to DNA damage and p53 activation, which in turn lead to either cell apoptosis or senescence, it remains unclear how mitotic defects trigger p53 activation. We show that BuGZ and Bub3, which are two mitotic regulators localized in the...
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| Publicat a: | J Cell Biol |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4411280/ https://ncbi.nlm.nih.gov/pubmed/25918225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201409073 |
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