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Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy

The bone marrow microenvironment plays an important role in acute lymphoblastic leukemia (ALL) cell proliferation, maintenance, and resistance to chemotherapy. Annexin II (ANX2) is abundantly expressed on bone marrow cells and complexes with p11 to form ANX2/p11-hetero-tetramer (ANX2T). We present e...

詳細記述

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書誌詳細
出版年:PLoS One
主要な著者: Gopalakrishnapillai, Anilkumar, Kolb, E. Anders, Dhanan, Priyanka, Mason, Robert W., Napper, Andrew, Barwe, Sonali P.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605480/
https://ncbi.nlm.nih.gov/pubmed/26465153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140564
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