Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy

The bone marrow microenvironment plays an important role in acute lymphoblastic leukemia (ALL) cell proliferation, maintenance, and resistance to chemotherapy. Annexin II (ANX2) is abundantly expressed on bone marrow cells and complexes with p11 to form ANX2/p11-hetero-tetramer (ANX2T). We present e...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gopalakrishnapillai, Anilkumar, Kolb, E. Anders, Dhanan, Priyanka, Mason, Robert W., Napper, Andrew, Barwe, Sonali P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605480/
https://ncbi.nlm.nih.gov/pubmed/26465153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140564
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