Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy

The bone marrow microenvironment plays an important role in acute lymphoblastic leukemia (ALL) cell proliferation, maintenance, and resistance to chemotherapy. Annexin II (ANX2) is abundantly expressed on bone marrow cells and complexes with p11 to form ANX2/p11-hetero-tetramer (ANX2T). We present e...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Gopalakrishnapillai, Anilkumar, Kolb, E. Anders, Dhanan, Priyanka, Mason, Robert W., Napper, Andrew, Barwe, Sonali P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605480/
https://ncbi.nlm.nih.gov/pubmed/26465153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140564
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