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Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia
Aberrations in epigenetic modifications contribute to leukemogenesis in childhood acute myeloid leukemia (AML). We combined DNA hypomethylating agent azacitidine with histone deacetylase inhibitor panobinostat in preclinical models of childhood AML. Synergistic cytotoxic effect upon treatment with a...
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| Publicado no: | Leuk Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5507334/ https://ncbi.nlm.nih.gov/pubmed/28505595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2017.05.004 |
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