Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia

Aberrations in epigenetic modifications contribute to leukemogenesis in childhood acute myeloid leukemia (AML). We combined DNA hypomethylating agent azacitidine with histone deacetylase inhibitor panobinostat in preclinical models of childhood AML. Synergistic cytotoxic effect upon treatment with a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Leuk Res
Egile Nagusiak: Gopalakrishnapillai, Anilkumar, Kolb, E. Anders, McCahan, Suzanne M., Barwe, Sonali P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507334/
https://ncbi.nlm.nih.gov/pubmed/28505595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2017.05.004
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