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Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs
One of the major obstacles to the pharmaceutical success of oligonucleotide therapeutics (ONTs) is efficient delivery from the point of injection to the intracellular setting where functional gene silencing occurs. In particular, a significant fraction of internalized ONTs are nonproductively seques...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4605330/ https://ncbi.nlm.nih.gov/pubmed/26400165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv942 |
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