Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs

One of the major obstacles to the pharmaceutical success of oligonucleotide therapeutics (ONTs) is efficient delivery from the point of injection to the intracellular setting where functional gene silencing occurs. In particular, a significant fraction of internalized ONTs are nonproductively seques...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Osborn, Maire F., Alterman, Julia F., Nikan, Mehran, Cao, Hong, Didiot, Marie C., Hassler, Matthew R., Coles, Andrew H., Khvorova, Anastasia
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Chemical Biology and Nucleic Acid Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605330/
https://ncbi.nlm.nih.gov/pubmed/26400165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv942
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