Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs

One of the major obstacles to the pharmaceutical success of oligonucleotide therapeutics (ONTs) is efficient delivery from the point of injection to the intracellular setting where functional gene silencing occurs. In particular, a significant fraction of internalized ONTs are nonproductively seques...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Osborn, Maire F., Alterman, Julia F., Nikan, Mehran, Cao, Hong, Didiot, Marie C., Hassler, Matthew R., Coles, Andrew H., Khvorova, Anastasia
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Chemical Biology and Nucleic Acid Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605330/
https://ncbi.nlm.nih.gov/pubmed/26400165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv942
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