A ruthenium dimer complex with a flexible linker slowly threads between DNA bases in two distinct steps

Several multi-component DNA intercalating small molecules have been designed around ruthenium-based intercalating monomers to optimize DNA binding properties for therapeutic use. Here we probe the DNA binding ligand [μ-C4(cpdppz)(2)(phen)(4)Ru(2)](4+), which consists of two Ru(phen)(2)dppz(2+) moiet...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Bahira, Meriem, McCauley, Micah J., Almaqwashi, Ali A., Lincoln, Per, Westerlund, Fredrik, Rouzina, Ioulia, Williams, Mark C.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Molecular Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605314/
https://ncbi.nlm.nih.gov/pubmed/26365236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv864
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