Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex

DNA intercalation by threading is expected to yield high affinity and slow dissociation, properties desirable for DNA-targeted therapeutics. To measure these properties, we utilize single molecule DNA stretching to quantify both the binding affinity and the force-dependent threading intercalation ki...

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Bibliografske podrobnosti
Main Authors: Almaqwashi, Ali A., Paramanathan, Thayaparan, Lincoln, Per, Rouzina, Ioulia, Westerlund, Fredrik, Williams, Mark C.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Molecular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191423/
https://ncbi.nlm.nih.gov/pubmed/25245944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku859
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