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Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex
DNA intercalation by threading is expected to yield high affinity and slow dissociation, properties desirable for DNA-targeted therapeutics. To measure these properties, we utilize single molecule DNA stretching to quantify both the binding affinity and the force-dependent threading intercalation ki...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4191423/ https://ncbi.nlm.nih.gov/pubmed/25245944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku859 |
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