Single-molecule kinetics reveal microscopic mechanism by which High-Mobility Group B proteins alter DNA flexibility

Eukaryotic High-Mobility Group B (HMGB) proteins alter DNA elasticity while facilitating transcription, replication and DNA repair. We developed a new single-molecule method to probe non-specific DNA interactions for two HMGB homologs: the human HMGB2 box A domain and yeast Nhp6Ap, along with chimer...

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Bibliographic Details
Main Authors: McCauley, Micah J., Rueter, Emily M., Rouzina, Ioulia, Maher, L. James, Williams, Mark C.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592474/
https://ncbi.nlm.nih.gov/pubmed/23143110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1031
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