Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Giardia intestinalis Trophozoites

The methionyl-tRNA synthetase (MetRS) is a novel drug target for the protozoan pathogen Giardia intestinalis. This protist contains a single MetRS that is distinct from the human cytoplasmic MetRS. A panel of MetRS inhibitors was tested against recombinant Giardia MetRS, Giardia trophozoites, and ma...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Ranade, Ranae M., Zhang, Zhongsheng, Gillespie, J. Robert, Shibata, Sayaka, Verlinde, Christophe L. M. J., Hol, Wim G. J., Fan, Erkang, Buckner, Frederick S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604383/
https://ncbi.nlm.nih.gov/pubmed/26324270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01573-15
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