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Prion aggregate structure in yeast cells is determined by the Hsp104-Hsp110 disaggregase machinery

Prions consist of misfolded proteins that have adopted an infectious amyloid conformation. In vivo, prion biogenesis is intimately associated with the protein quality control machinery. Using electron tomography, we probed the effects of the heat shock protein Hsp70 chaperone system on the structure...

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Bibliografski detalji
Izdano u:J Cell Biol
Glavni autori: O’Driscoll, Jonathan, Clare, Daniel, Saibil, Helen
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602031/
https://ncbi.nlm.nih.gov/pubmed/26438827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201505104
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