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Structural basis for the disaggregase activity and regulation of Hsp104

The Hsp104 disaggregase is a two-ring ATPase machine that rescues various forms of non-native proteins including the highly resistant amyloid fibers. The structural-mechanistic underpinnings of how the recovery of toxic protein aggregates is promoted and how this potent unfolding activity is prevent...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Heuck, Alexander, Schitter-Sollner, Sonja, Suskiewicz, Marcin Józef, Kurzbauer, Robert, Kley, Juliane, Schleiffer, Alexander, Rombaut, Pascaline, Herzog, Franz, Clausen, Tim
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130295/
https://ncbi.nlm.nih.gov/pubmed/27901467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21516
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