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Structural basis for the disaggregase activity and regulation of Hsp104
The Hsp104 disaggregase is a two-ring ATPase machine that rescues various forms of non-native proteins including the highly resistant amyloid fibers. The structural-mechanistic underpinnings of how the recovery of toxic protein aggregates is promoted and how this potent unfolding activity is prevent...
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Publicado en: | eLife |
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Main Authors: | , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Assuntos: | |
Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5130295/ https://ncbi.nlm.nih.gov/pubmed/27901467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21516 |
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