Structural determinants for protein unfolding and translocation by the Hsp104 protein disaggregase

The ring-forming Hsp104 ATPase cooperates with Hsp70 and Hsp40 molecular chaperones to rescue stress-damaged proteins from both amorphous and amyloid-forming aggregates. The ability to do so relies upon pore loops present in the first ATP-binding domain (AAA-1; loop-1 and loop-2 ) and in the second...

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Bibliographic Details
Published in:Biosci Rep
Main Authors: Lee, Jungsoon, Sung, Nuri, Yeo, Lythou, Chang, Changsoo, Lee, Sukyeong, Tsai, Francis T.F.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741831/
https://ncbi.nlm.nih.gov/pubmed/29175998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20171399
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