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Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation

Hsp104 is a ring-forming, ATP-driven molecular machine that recovers functional protein from both stress-denatured and amyloid-forming aggregates. Although Hsp104 shares a common architecture with Clp/Hsp100 protein unfoldases, different and seemingly conflicting 3D structures have been reported. Ex...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Lee, Sukyeong, Roh, Soung Hun, Lee, Jungsoon, Sung, Nuri, Liu, Jun, Tsai, Francis T.F.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347426/
https://ncbi.nlm.nih.gov/pubmed/30605683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.037
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