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A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX
Human carbonic anhydrase (CA; EC 4.2.1.1) isoform IX (CA IX) is an extracellular zinc metalloenzyme that catalyzes the reversible hydration of CO(2) to HCO(3) (−), thereby playing a role in pH regulation. The majority of normal functioning cells exhibit low-level expression of CA IX. However, in can...
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| Udgivet i: | Acta Crystallogr F Struct Biol Commun |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
International Union of Crystallography
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4601603/ https://ncbi.nlm.nih.gov/pubmed/26457530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X1501239X |
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