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A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX

Human carbonic anhydrase (CA; EC 4.2.1.1) isoform IX (CA IX) is an extracellular zinc metalloenzyme that catalyzes the reversible hydration of CO(2) to HCO(3) (−), thereby playing a role in pH regulation. The majority of normal functioning cells exhibit low-level expression of CA IX. However, in can...

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Detalles Bibliográficos
Publicado en:Acta Crystallogr F Struct Biol Commun
Autores principales: Pinard, Melissa A., Aggarwal, Mayank, Mahon, Brian P., Tu, Chingkuang, McKenna, Robert
Formato: Artigo
Lenguaje:Inglês
Publicado: International Union of Crystallography 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601603/
https://ncbi.nlm.nih.gov/pubmed/26457530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X1501239X
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