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A probabilistic model of human variability in physiology for future application to dose reconstruction and QIVIVE

The risk assessment of environmental chemicals and drugs is undergoing a paradigm shift in approach which seeks the full replacement of animal testing with high throughput, mechanistic, in vitro systems. This new approach will be reliant on the measurement in vitro, of concentration-dependent respon...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: McNally, Kevin, Loizou, George D.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600921/
https://ncbi.nlm.nih.gov/pubmed/26528180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00213
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