The application of global sensitivity analysis in the development of a physiologically based pharmacokinetic model for m-xylene and ethanol co-exposure in humans

Global sensitivity analysis (SA) was used during the development phase of a binary chemical physiologically based pharmacokinetic (PBPK) model used for the analysis of m-xylene and ethanol co-exposure in humans. SA was used to identify those parameters which had the most significant impact on variab...

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Udgivet i:Front Pharmacol
Main Authors: Loizou, George D., McNally, Kevin, Jones, Kate, Cocker, John
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485162/
https://ncbi.nlm.nih.gov/pubmed/26175688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00135
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