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Encapsulation of temozolomide in a tumor-targeting nanocomplex enhances anti-cancer efficacy and reduces toxicity in a mouse model of glioblastoma

Although temozolomide (TMZ) is the current first-line chemotherapy for glioblastoma multiforme (GBM), most patients either do not respond or ultimately fail TMZ treatment. Both intrinsic tumor resistance and limited access of TMZ to brain tumors as a result of the blood-brain barrier (BBB) contribut...

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Bibliografiske detaljer
Udgivet i:Cancer Lett
Main Authors: Kim, Sang-Soo, Rait, Antonina, Kim, Eric, DeMarco, James, Pirollo, Kathleen F., Chang, Esther H.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600672/
https://ncbi.nlm.nih.gov/pubmed/26325605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.08.022
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