A Nanoparticle Carrying the p53 Gene Targets Tumors Including Cancer Stem Cells, Sensitizes Glioblastoma to Chemotherapy and Improves Survival

[Image: see text] Temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) has been linked to upregulation of O(6)-methylguanine-DNA methyltransferase (MGMT). Wild-type (wt) p53 was previously shown to down-modulate MGMT. However, p53 therapy for GBM is limited by lack of efficient delivery ac...

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Detalhes bibliográficos
Main Authors: Kim, Sang-Soo, Rait, Antonina, Kim, Eric, Pirollo, Kathleen F., Nishida, Maki, Farkas, Natalia, Dagata, John A., Chang, Esther H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076028/
https://ncbi.nlm.nih.gov/pubmed/24811110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn5014484
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