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A Tumor-targeting p53 Nanodelivery System Limits Chemoresistance to Temozolomide Prolonging Survival in a Mouse Model of Glioblastoma Multiforme

Development of temozolomide (TMZ) resistance contributes to the poor prognosis for glioblastoma multiforme (GBM) patients. It was previously demonstrated that delivery of exogenous wild-type tumor suppressor gene p53 via a tumor-targeted nanocomplex (SGT-53) which crosses the blood-brain barrier cou...

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Detalhes bibliográficos
Publicado no:Nanomedicine
Main Authors: Kim, Sang-Soo, Rait, Antonina, Kim, Eric, Pirollo, Kathleen F., Chang, Esther H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330129/
https://ncbi.nlm.nih.gov/pubmed/25240597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2014.09.005
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