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High Affinity α3β4 Nicotinic Acetylcholine Receptor Ligands AT-1001 and AT-1012 Attenuate Cocaine-Induced Conditioned Place Preference and Behavioral Sensitization in Mice
Cholinergic signaling via the nicotinic acetylcholine receptors (nAChRs) in the mesolimbic circuitry is involved in the rewarding effects of abused drugs such as cocaine and opioids. In mouse studies, nonselective nAChR antagonist mecamylamine blocks cocaine-induced conditioned place preference (CPP...
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| Publié dans: | Biochem Pharmacol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4600456/ https://ncbi.nlm.nih.gov/pubmed/26256075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.08.083 |
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