AT–1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology

BACKGROUND AND PURPOSE: The α3β4 subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediating nicotine reinforcement processes. AT-1001 has been recently described as a high-affinity and selective α3β4 nAChR antagonist that blocks nicotine self-administration in rats. The a...

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Publicat a:Br J Pharmacol
Autors principals: Cippitelli, Andrea, Wu, Jinhua, Gaiolini, Kelly A, Mercatelli, Daniela, Schoch, Jennifer, Gorman, Michelle, Ramirez, Alejandra, Ciccocioppo, Roberto, Khroyan, Taline V, Yasuda, Dennis, Zaveri, Nurulain T, Pascual, Conrado, Xie, Xinmin (Simon), Toll, Lawrence
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376460/
https://ncbi.nlm.nih.gov/pubmed/25440006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13034
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