Estrogen and progesterone decrease Let-7f miRNA expression and increase IL-23/IL-23R signaling and IL-17A production in severe asthma

BACKGROUND: Women have an increased prevalence of severe asthma compared to men. IL-17A is associated with severe asthma and requires IL-23 receptor (IL-23R) signaling, which is negatively regulated by Let-7f miRNA. OBJECTIVE: Determine the mechanism by which 17β-estradiol (E2) and progesterone (P4)...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Allergy Clin Immunol
Huvudupphovsmän: Newcomb, Dawn C., Cephus, Jacqueline Yvonne, Boswell, Madison G., Fahrenholz, John M., Langley, Emily W., Feldman, Amy S., Zhou, Weisong, Dulek, Daniel E., Goleniewska, Kasia, Woodward, Kimberly B., Sevin, Carla M., Hamilton, Robert G., Kolls, Jay, Peebles, R. Stokes
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600442/
https://ncbi.nlm.nih.gov/pubmed/26242299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.05.046
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk