Estrogen and progesterone decrease Let-7f miRNA expression and increase IL-23/IL-23R signaling and IL-17A production in severe asthma

BACKGROUND: Women have an increased prevalence of severe asthma compared to men. IL-17A is associated with severe asthma and requires IL-23 receptor (IL-23R) signaling, which is negatively regulated by Let-7f miRNA. OBJECTIVE: Determine the mechanism by which 17β-estradiol (E2) and progesterone (P4)...

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Publicado no:J Allergy Clin Immunol
Main Authors: Newcomb, Dawn C., Cephus, Jacqueline Yvonne, Boswell, Madison G., Fahrenholz, John M., Langley, Emily W., Feldman, Amy S., Zhou, Weisong, Dulek, Daniel E., Goleniewska, Kasia, Woodward, Kimberly B., Sevin, Carla M., Hamilton, Robert G., Kolls, Jay, Peebles, R. Stokes
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600442/
https://ncbi.nlm.nih.gov/pubmed/26242299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.05.046
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