Estrogen and progesterone decrease Let-7f miRNA expression and increase IL-23/IL-23R signaling and IL-17A production in severe asthma

BACKGROUND: Women have an increased prevalence of severe asthma compared to men. IL-17A is associated with severe asthma and requires IL-23 receptor (IL-23R) signaling, which is negatively regulated by Let-7f miRNA. OBJECTIVE: Determine the mechanism by which 17β-estradiol (E2) and progesterone (P4)...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Allergy Clin Immunol
मुख्य लेखकों: Newcomb, Dawn C., Cephus, Jacqueline Yvonne, Boswell, Madison G., Fahrenholz, John M., Langley, Emily W., Feldman, Amy S., Zhou, Weisong, Dulek, Daniel E., Goleniewska, Kasia, Woodward, Kimberly B., Sevin, Carla M., Hamilton, Robert G., Kolls, Jay, Peebles, R. Stokes
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600442/
https://ncbi.nlm.nih.gov/pubmed/26242299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.05.046
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