Human Th17 Cells Express a Functional IL-13 Receptor and IL-13 Attenuates IL-17A Production

BACKGROUND: IL-13 is a central mediator of airway responsiveness and mucus expression in allergic airway inflammation and IL-13 is currently a therapeutic target for asthma. However, little is known about how IL-13 regulates human CD4+ T cell lineages because the IL-13 receptor α1 (IL-13Rα1), a subu...

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Main Authors: Newcomb, Dawn C, Boswell, Madison G, Zhou, Weisong, Huckabee, Matthew M, Goleniewska, Kasia, Sevin, Carla M, Hershey, Gurjit K Khurana, Kolls, Jay K, Peebles, R. Stokes
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916096/
https://ncbi.nlm.nih.gov/pubmed/21236478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2010.11.043
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