Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a(+/−) mice

Carney Complex (CNC), a human genetic syndrome predisposing to multiple neoplasias, is associated with bone lesions such as osteochondromyxomas (OMX). The most frequent cause for CNC is PRKAR1A deficiency; PRKAR1A codes for type-I regulatory subunit of protein kinase A (PKA). Prkar1a(+/−) mice devel...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Liu, Sisi, Saloustros, Emmanouil, Mertz, Edward L., Tsang, Kitman, Starost, Matthew F., Salpea, Paraskevi, Faucz, Fabio R., Szarek, Eva, Nesterova, Maria, Leikin, Sergey, Stratakis, Constantine A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599668/
https://ncbi.nlm.nih.gov/pubmed/26246497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv320
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