Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis

BACKGROUND: Carney complex (CNC) is a rare disease associated with multiple neoplasias, including a predisposition to pancreatic tumors; it is caused most frequently by inactivation of the PRKAR1A gene, a regulator of the cyclic AMP (cAMP)-dependent kinase (PKA). METHODS: We created null alleles of...

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Detalhes bibliográficos
Publicado no:Endocr Relat Cancer
Main Authors: Saloustros, Emmanouil, Salpea, Paraskevi, Starost, Matthew, Liu, Sissi, Faucz, Fabio R., London, Edra, Szarek, Eva, Song, Woo-Jin, Hussain, Mehboob, Stratakis, Constantine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123945/
https://ncbi.nlm.nih.gov/pubmed/27803029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-16-0443
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