Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities

Pentafluorosulfanyl-containing analogs of flufenamic acid have been synthesized in high yields. Computationally, pK(a), logP and logD values have been determined. Initial bioactivity studies reveal effects as ion channel modulators and inhibitory activities on aldo-keto reductase 1C3 (AKR1C3) as wel...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Hendriks, Christine M. M., Penning, Trevor M., Zang, Tianzhu, Wiemuth, Dominik, Gründer, Stefan, Sanhueza, Italo A., Schoenebeck, Franziska, Bolm, Carsten
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599580/
https://ncbi.nlm.nih.gov/pubmed/26372652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.09.012
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