Enhanced production of a single domain antibody with an engineered stabilizing extra disulfide bond

BACKGROUND: Single domain antibodies derived from the variable region of the unique heavy chain antibodies found in camelids yield high affinity and regenerable recognition elements. Adding an additional disulfide bond that bridges framework regions is a proven method to increase their melting tempe...

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Publicat a:Microb Cell Fact
Autors principals: Liu, Jinny L., Goldman, Ellen R., Zabetakis, Dan, Walper, Scott A., Turner, Kendrick B., Shriver-Lake, Lisa C., Anderson, George P.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599338/
https://ncbi.nlm.nih.gov/pubmed/26449768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0340-3
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